Who plays Mrs. Wheeler mother? What actor takes on the role of Karen Wheeler in the series? Who is the performer behind Karen Wheeler? Karen is portrayed by who? What actress acts as the character of Karen Wheeler on the show? Who is the talent personifying Karen the mother's character to life? Which actress takes on the role of Karen Mrs. Wheeler in the series? Who takes on the part of Karen Wheeler? Who is the talented individual embodying Karen the mother on the show? What actress incarnates the character of Karen Wheeler to the screen?