Whom portrays Mrs. Wheeler Wheeler? Which actor takes on the role of Karen Wheeler in the show? Who is the performer behind Karen Wheeler? Mrs. Wheeler is depicted by who? Who acts as the character of Karen Wheeler on the series? Who is the talent personifying Karen the mother's character to life? What performer takes on the role of Karen Wheeler in the series? Whoever acts Karen Wheeler? Whom is the talented individual embodying Karen the mother on the series? What actor brings the character of Karen Mrs. Wheeler to the screen?