Who acts Mrs. Wheeler Wheeler? What actor assumes the role of Karen Wheeler in the series? Who is the performer behind Karen Wheeler? Karen is portrayed by whom? Who acts as the character of Karen the mother on the show? Whom is the talent personifying Karen the mother's character to life? What performer takes on the role of Karen Wheeler in the television show? Whoever performs Karen Mrs. Wheeler? Whom is the talented individual portraying Karen Wheeler on the series? What actress brings the character of Karen Wheeler to the screen?